Celiac Disease: Understanding Celiac Disease And What It Does To The Body
Celiac disease is (Prescription Drugs Without Prescriptions) an autoimmune disease, which is a disease where the immune system attacks the body. This gets activated when the person ingests gluten. Some people think that because celiac disease is an autoimmune disease, that someone with celiac disease has a compromised immune system. This is not true! Actually, the opposite is true. The immune system in people with celiac disease is working overtime to protect the body against threats such as gluten.
How the intestines are supposed to work
You have guts, do you know how they work? Skipping a bunch of different steps, I will start this explanation in the upper part of the small intestine. The food has already been chewed, swallowed, passed through the stomach and broken down by enzymes into nutrients that the body can use to nourish itself.
The small intestine is lined with hairlike projections called villi. The purpose of the villi is to increase the surface area of the intestine so that they have more room to absorb important nutrients. The lining of the small intestine is basically a solid wall. The cells on the lining are joined by tight junctions When the body is ready to absorb the nutrients that it takes in, these tight junctions open the space between the cells and let the good stuff in while keeping the bad stuff out. These junctions know how far to open with the help of a protein called zonulin. This protein is the gatekeeper, which opens the tight junctions far enough to let the good stuff in, but keeps the bad stuff out.
How your intestines work with celiac disease
When someone with celiac disease eats gluten, everything goes along just fine until the gluten reaches the small intestine. The first thing that goes wrong is that wheat causes the body, in all humans, not just celiacs, to produce too much zonulin. The extra zonulin causes the junctions between the cells in the small intestine to open too wide, then there is a party in the bloodstream and everything can get into the bloodstream that shouldn’t be there, including toxins and pieces of gluten. When stuff leaks through the intestinal wall that normally shouldn’t be able to, the condition is called leaky gut syndrome.
No, thanks to the excess of zonulin that was released because you ingested gluten, the gluten fragment makes its way into the bloodstream. In people with celiac disease, the body sees gluten fragments as invaders or toxins that shouldn’t be there. So it launches an all out attack against these invaders. But, because celiac disease is an autoimmune disease, the body also attacks itself.
An autoimmune disease is one in which the body’s immune system produces antibodies that react against normal, healthy tissue, causing inflammation and damage. Celiac disease is unique in that it is the only autoimmune disease for which people know the trigger that sets off the response. Specifically, the body attacks the villi on the lining of the small intestine. As the villi get chopped down, blunted is the technical term, they can no longer be effective in absorbing nutrients. That is why you see malabsorption and nutrient deficiencies in people with celiac disease who still eat gluten.
Because the food is just passing through without being absorbed, you sometimes see diarrhea. But think about this: The small intestine is nearly 22 feet long, and damage from celiac disease begins at the top of the small intestine, there is a lot of small intestine to compensate for the damaged part that isn’t able to do its job. This means that by the time you have diarrhea, you are pretty sick. effects of celiac disease
Celiac disease affects all parts of the body, in particular the small intestine and I hope you now understand how this disease affects the human body.
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